Substance P Activates Both Contractile and Inflammatory Pathways in Lymphatics Through the Neurokinin Receptors NK1R and NK3R
نویسندگان
چکیده
منابع مشابه
Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R.
OBJECTIVE The aim of this study was to elucidate the molecular signaling mechanisms by which substance P (SP) modulates lymphatic muscle contraction and to determine whether SP stimulates both contractile as well as inflammatory pathways in the lymphatics. METHODS A rat mesenteric lymphatic muscle cell culture model (RMLMCs) and known specific pharmacological inhibitors were utilized to delin...
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ژورنال
عنوان ژورنال: Microcirculation
سال: 2010
ISSN: 1073-9688
DOI: 10.1111/j.1549-8719.2010.00064.x